Odontogenic keratocyst because of its behavior, many oral pathologists now consider the okc an odontogenic tumor that has a cystic form 2005 classi. Ameloblastoma is a fairly common tumor of nigerian africans accounting for 73% of odontogenic tumors and 24% of all tumors and tumor like lesions of the oral and perioral structures. Simple diagnostic approach for mandible and maxilla lesions. Its characterized by proliferation of cementumlike tis sue and in almost all cases tends to be associated with an erupted permanent tooth, most often the first mo lar. Pdf latest update of odontogenic tumors in alexandria university. Also location is most common in maxillary anterior tooth 1. Notch signaling affects oral neoplasm cell differentiation. Odontogenic keratocysts make up around 19% of jaw cysts. Adenomatoid odontogenic tumour of mandibular anterior. Odontogenic carcinomas are the malignant epithelial odontogenic neoplasms which comprise the first category of the 2005 who classification of odontogenic tumours.
Iarc has been responsible for the who classification of tumours, also known as the who blue books, since the 3rd edition 20002005, which covered all organ sites in 10 volumes. Files of patients younger than 20 years of age diagnosed over a period of 26 years with odontogenic tumours were retrieved and analysed for gender, site, tumour. The origin of odontogenic tumors odontogenic tissues ectodermal mesenchymalepithelium c. They are principally jaw lesions but some may present as localized gingival.
Feb 28, 2017 this article provides a summary of the changes to chapter 4 tumours of the oral cavity and mobile tongue and chapter 8 odontogenic and maxillofacial bone tumours. An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes examples include. It describes the epidemiologic, radiologic, and histopathologic features of presently known neoplasms and hamartomatous or tumorlike lesions arising from the toothforming structures, as well as a number of distinctive jaw lesions that must be distinguished from odontogenic. Classified as an odontogenic carcinoma, which includes.
Some are composed only of odontogenic epithelium, while many are mixed i. The characteristics of each cancer type, including diagnostic criteria, pathological features, and associated molecular alterations, are described and illustrated in. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic. Clinical, radiological and therapeutic features of. It most often affects the posterior mandible and most commonly presents in the third decade of life. Odontogenesis, odontogenic cysts, and odontogenic tumors. The socalled calcifying epithelial odontogenic tumour in dogs and cats amyloidproducing odontogenic tumour. In other words, odontogenic tumors arise from odontogenic tissues. Although mostly benign neoplasms of the central jaw bones, they often show a destructive and recurrent behaviour 8. An adenomatoid odontogenic tumour aot is a rare odontogenic tumour that is often misdiagnosed as an odontogenic cyst. D, frcpath assistant prof of general pathology senior lecturer of oral pathology and oral histology slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. They may arise from the epithelial part of the tooth germ, the mesenchymal part or from both. These tumours are believed to take origin from the epithelial components of the odontogenic.
Odontogenic cysts which were eliminated from the 3rd 2005 edition were included in the 4th edition as well as other unique allied conditons of the jaws. Several tumors exist, which only appear to occur in the jaws. Nonodontogenic tumours of the jaw originating from bone and its mesenchymal tissue represent a large heterogeneous group of diverse diseases. Tumors are also called neoplasms, which means that they are composed of new and actively growing tissue. The odontogenic cysts are a diverse groups of odontogenic lesions of the jaws the radicular cyst is an inflammatory lesion, and although by far the most common, it is clinically easy to diagnose and manage other cysts are less frequently encountered and some e. Odontogenic tumor article about odontogenic tumor by the. Keratocystic odontogenic tumour, odontogenic keratocyst, odontogenic cysts, keratocyst, carnoys solution. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair click the link for more information. Update from the 4th edition of the world health organization.
The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. Keratocystic odontogenic and ameloblastoma are preferably treated with surgical excision and resection, although marsuplization is a recommended option to save the vital structures in case of okc. Odontogenic myxoma, odontogenic fibromyxoma, maxilla 1. For this reason, this new edition restores the odontogenic keratocyst and calcifying odontogenic cyst to the classification of odontogenic cysts and.
Calcifying epithelial odontogenic tumors adenomatoid odontogenic tumor. Sanchezburgos r, gonzalezmartinmoro j, perezfernandez e, burguenogarcia m. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Recently, the classification and nomenclature of odontogenic tumours has been updated. Amongst all oral lesions, prevalence of odontogenic tumor is 0. The glandular odontogenic cyst goc is a very rare and relatively new entity. Non odontogenic tumours of the jaw originating from bone and its mesenchymal tissue represent a large heterogeneous group of diverse diseases.
Calcified substances form in many of these tumors and may be bone, cementum, amorphous and nonspecific calcifications, or a combination of these. Current concepts of odontogenic tumours e an update daniel j brierley paul m speight richard ck jordan abstract odontogenic tumours can pose signi. New findings and controversies in odontogenic tumors. According to this classification, benign odontogenic tumors are classified as follows. Odontogenic tumor odontogenic keratocyst keratinocystic odontogenic tumor three important things associated with this diagnosis. According to the world health organization who, they originate from odontogenic ectomesenchyme, with or without odontogenic epithelium 2 3. Comparison of components of odontogenic cyst fluids. Odontogenic tumors comprise a complex group of lesions with varied histopathological and clinical features.
Dec 03, 2019 the glandular odontogenic cyst goc is a very rare and relatively new entity. Morgan odontogenic tumors comprise a range of disorders of growth, from malignant and benign neoplasms, to malformations of dental tissues of selflimited growth. Ameloblastomaderived from the remnants of the dental lamina benign yet locally agressive most common site is the posterior mandible avg age 38 years very aggressive and grows quite large, watch them for 910 years after its removed. Extramedullary plasmacytomas arise outside of bone, are typically mucocutaneous in location and occur most commonly in the mouth, on the feet or trunk and in the ears. Clinically seen on gingiva as a hard swelling, often between the teeth. Abstract adenomatoid odontogenic tumor is the most common tumor between second and third decade of life. Odontogenic and non odontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Odontogenic tumors comprise a range of disorders of growth, from malignant and benign neoplasms, to malformations of dental tissues of selflimited growth. However, the 3rd edition went further and divided some lesions into subtypes. Odontogenic tumours manifesting in the first two decades of life in a. New tumour entities in the 4th edition of the world health.
Cementoblastoma is a rare benign lesion that repre sents less than 1% of all odontogenic tumours. By 1992, however, it had become obvious that this cyst is not salivary but odontogenic in origin and as such the name was changed to glandular odontogenic cyst. Odontogenic tumors, generally considered to be rare, are actually common if the odontogenic benign tumors are included. First reported in 1987, by padaychee and van wyk, it was initially called a sialodontogenic cyst. Their behaviour varies from neoplastic to hamartomatous. Update from the 4th edition of the world health organization classification of head and neck tumours. Odontogenic tumors 27 questions by krissabella last updated. In this chapter, only those composed of both odontogenic epithelium and mesenchyme will be dealt with, separate chapters being devoted to the. Chapter 21 odontogenic and non odontogenic tumors of the jaws introduction. Pathogenesis and nomenclature of odontogenic carcinomas. Enucleation gives very good prognosis for the treatment of dentigerous cyst, calcifying epithelial odontogenic tumor. New findings in odontogenic tumors e557 1% of all ot in most of the published series worldwide.
Barnes l, eveson jw, reichart p et al eds world health organization classification of tumours. Biochemical and cytological comparison of keratocystic odontogenic tumours to nonkeratinising odontogenic cysts fluid. The 4th edition of the world health organizations classification of head and neck tumours was published in january of 2017. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Some tumors are true neoplasms, while some are hamartomas developmental malformations. Results a total of 7259 biopsy records of elderly participants were analysed. Consists of variably cellular fibrocollagenous tissue with scattered, small, inactive odontogenic epithelium in strands, cords or nests calcification can be seen in association with odontogenic epithelium and when extensive could consider classification as ossifying variant of odontogenic fibroma. Although they do not normally contain odontogenic tissue, they are probably odontogenic because of their site of origin. The nomenclature of odontogenic and nonodontogenic cysts of the oral region is varied. Odontogenic tumor definition of odontogenic tumor by. Overall, odontogenic tumors are rare and form only a small proportion of the lesions found in the jaw.
This article provides a summary of the changes to chapter 4 tumours of the oral cavity and mobile tongue and chapter 8 odontogenic and maxillofacial bone tumours. Clinical, radiological and therapeutic features of keratocystic odontogenic tumours. The latest who classification of odontogenic tumors was published in pathology and genetics. These new views will be incorporated in this article where appropriate. Recurrent kras g12v pathogenic mutation in adenomatoid odontogenic tumours. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. The last update of these tumors was published in early 2017. Nov 20, 2014 the latest who classification of odontogenic tumors was published in pathology and genetics. Odontogenic tumors encompass a group of lesions that share a common origin from odontogenic tissues. Comparison of proliferating cell nuclear antigen expression. This book greatly expands the body of knowledge in the field of odontogenic tumor pathology. Odontogenic tumours are derived from these toothforming tissues, either the epithelial or the ectomesenchymal or both.
Keratinocystic odontogenic tumor odontogenic keratocyst keratinocystic odontogenic tumor three important things associated with this diagnosis. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. Painless but it can present fast growth and have locally aggressive behaviour. Ameloblastoma, a type of odontogenic tumor involving ameloblasts. Odontogenic keratocyst simulating lateral periodontal cyst. It is generally intraosseous, but can also occur rarely in peripheral locations. Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. Due to significant characteristics, they differ from bone tumours seen elsewhere in the skeleton. Nonneoplastic lesions, such as cysts, hyperplasia, and inflammatory or infections processes, present a varied set of pathologies and treatment recommendations. According to who 2005, ghost cell odontogenic carcinoma is a malignant epithelial tumor with features of calcifying cystic odontogenic tumor or dentinogenic ghost cell tumor. It occurs most often in the second and third decades of life and most common located within mandible. Introduction odontogenic myxomas om are benign tumours first described in the literature by thoma and goldman in 1947 1. This is a slowgrowing, benign neoplasm characterized by the proliferation of fibrous tissue in which isolated islands or strands of odontogenic epithelium are present. Introduction ameloblastomas are rare epithelial tumours of presumed odontogenic origin, constituting between 11 and 18% of all odontogenic tumours 3,21.
Our knowledge and understanding continues to evolve and it is clearly time for a more contemporary classification and discussion of odontogenic tumors. Odontogenic tumours both the 2nd and 3rd editions divided the odontogenic tumours into groups or subdivisions depending on the types of odontogenic tissues involved and on the degree of inductive change leading to hard tissue formation 2, 3. Relation to gorlin syndrome odontogenic keratocyst can be in the location of any odontogenic cyst. Even using this broad definition, ots are rare lesions that account for odontogenic tumor aot is an uncommon benign odontogenic lesion that affects young patients associated with an impacted tooth, usually canine. At the time of writing 2016, it is still the most widely used classification system although a new revision is due to come up in 2017. Osteosarcomas occur more commonly in the appendicular than axial skeleton. Patidar m, shetty p, patidar n, mittal s, singh h, chethna. They are rare in patients under the age of 10 or over t he age of.
Nov 14, 2018 odontogenic tumors, generally considered to be rare, are actually common if the odontogenic benign tumors are included. The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. Odontogenic tumors questions and study guide quizlet. This retrospective study was intended to assess the frequency and distribution of different types of odontogenic tumors. In 1992 who published the second edition of histological typing of odontogenic tumors. Odontogenic tumours are broadly classified into benign and malignant odontogenic tumours. Discussion aot is a benign, noninvasive odontogenic lesion showing slow growth. Molecular profiling of odontogenic tumors pilot study in. Morgan odontogenic tumors comprise a range of disorders of growth, from malignant and benign neoplasms, to malformations of dental tissues of. Odontogenic tumors ot are derived from toothforming elements and for the purposes of this chapter include lesions that are not definitively neoplastic. Aot accounts for about 19% of all odontogenic tumours.
1617 583 992 890 670 569 313 1148 562 1149 134 1421 1257 1664 588 1205 329 925 350 1025 482 236 296 110 1147 458 486 1281 1547 324 873 226 561 1348 295 92 206 846 873 637 487 819